FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF NAPROXEN SODIUM

Objective: The aim of this investigation was to prepare ODFs containing Naproxen Sodium, an NSAID, using solvent casting method and evaluate them put together a dosage form which can be taken without water, is easy administer, has rapid onset action surmount first pass metabolism. Six distinct formulations naproxen sodium ODF (F1-F6) were created in by varying the quantity croscarmellose sodium, super disintegrant.
 Methods: Sodium ODF’s prepared method. Evaluation done considering various parameters such as film thickness, folding endurance, disintegration time, surface pH, weight variation, vitro dissolution test, content uniformity FTIR.
 Results: F6 shown best fast release formulation terms time (less than 1 minute) (103.5 % after 30 min). Formulation F6's other characteristics, all within USP limit.
 Conclusion: By virtue quick self-administration water or chewing, oral dissolving (OFDF) one new technique enhance consumer acceptance. excellent intraoral fast-dissolving medication delivery wide range medicines, including neuroleptics, cardiovascular drugs, analgesics, anti-asthmatic, antihistamines drugs for erectile dysfunction, manufactured. From standpoint patient, oromucosal appealing since it allows administration need swallow, well better patient safety. As novel mechanism, notion quick-dissolving gained popularity. lowering dose frequency, will deliver optimum therapeutic efficacy, improved bioavailability, maximum stability. This also first-pass metabolism drugs. faster absorption from pre-gastric region, perhaps resulting action.